Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.5.1.4 extracted from

  • Norman, R.A.; McAlister, M.S.; Murray-Rust, J.; Movahedzadeh, F.; Stoker, N.G.; McDonald, N.Q.
    Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis (2002), Structure, 10, 393-402.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapour-diffusion method, crystal structure of native and selenomethionine-bound enzyme at 1.95 resolution, bound to the cofactor NAD+ Mycobacterium tuberculosis

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ enzyme contains Zn2+. The nicotinamide moiety of the NAD+ cofactor is in the syn conformation about the N-glycosidic bond and is held there by coordination with the Zn2+ ion. N233, D235 and D310 provide ligands to a water molecule that coordinates the zinc ion Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate key enzyme in inositol biosynthesis, rate-limiting step Mycobacterium tuberculosis 1D-inositol 3-phosphate
-
?

Synonyms

Synonyms Comment Organism
tbINO
-
Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mycobacterium tuberculosis