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Literature summary for 5.5.1.4 extracted from
- Purification, structure, and catalytic properties of L-myo-inositol-1-phosphate synthase from rat testis (1980), J. Biol. Chem., 255, 8458-8464.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NH4+ | stimulates | Rattus norvegicus |  |
General Stability
| General Stability | Organism |
|---|---|
| rapid loss of activity on freezing and thawing | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Deoxy-D-glucitol 6-phosphate | - |
Rattus norvegicus | |
| 2-deoxy-D-glucose 6-phosphate | - |
Rattus norvegicus | |
| Cd2+ | - |
Rattus norvegicus | |
| Co2+ | - |
Rattus norvegicus | |
| Cu2+ | - |
Rattus norvegicus | |
| Hg2+ | - |
Rattus norvegicus | |
| Zn2+ | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.26 | - |
D-glucose 6-phosphate | with addition of 20 mM NH4Cl | Rattus norvegicus | |
| 3.89 | - |
D-glucose 6-phosphate | - |
Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | stimulates 2fold and with added K+, 2.5fold | Rattus norvegicus | |
| Na+ | slight stimulation | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 68000 | - |
3 * 68000, SDS-PAGE | Rattus norvegicus |
| 210000 | - |
testis, gel filtration, PAGE, ultracentrifugal equilibrium sedimentation | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| testis | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.26 | - |
- |
Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, partially purified enzyme is stable for several months | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Glucose 6-phosphate | - |
Rattus norvegicus | L-myo-Inositol 1-phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | 3 * 68000, SDS-PAGE | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.7 | - |
- |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | required | Rattus norvegicus | |
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