Literature summary for 5.5.1.19 extracted from

Guo, F.; Zhou, W.; Zhang, J.; Xu, Q.; Deng, X.
Effect of the citrus lycopene beta-cyclase transgene on carotenoid metabolism in transgenic tomato fruits (2012), PLoS ONE, 7, e32221.

Application

Application	Comment	Organism
nutrition	as tomato fruits are rich in beta-carotene precursors, there is a substantial interest in engineering carotenoid synthesis in tomato with a view to enhancing its beta-carotene content, through recombinant expression of the gene encoding lypoene beta-cyclase, for improving the human diet	Citrus sp.

Cloned(Commentary)

Cloned (Comment)	Organism
gene Lycb-1, constitutive heterologous expression in Solanum lycopersicum fruits. In the transgenic line, the downstream alpha-branch metabolic fluxes are repressed during the three developmental stages while alpha-carotene content increases in the ripe stage, the beta-carotene level of transformant increases 4.1fold, and the total carotenoid content increases by 30% in the fruits. The constitutive expression of Lycb-1 affects a number of pathways including the synthesis of fatty acids, flavonoids and phenylpropanoids, the degradation of limonene and pinene, starch and sucrose metabolism and photosynthesis. Carotenoids contents in transgenic fruits at different stages of ripening, overview	Citrus sp.

Cloned (Comment)

Organism

gene Lycb-1, constitutive heterologous expression in Solanum lycopersicum fruits. In the transgenic line, the downstream alpha-branch metabolic fluxes are repressed during the three developmental stages while alpha-carotene content increases in the ripe stage, the beta-carotene level of transformant increases 4.1fold, and the total carotenoid content increases by 30% in the fruits. The constitutive expression of Lycb-1 affects a number of pathways including the synthesis of fatty acids, flavonoids and phenylpropanoids, the degradation of limonene and pinene, starch and sucrose metabolism and photosynthesis. Carotenoids contents in transgenic fruits at different stages of ripening, overview

Citrus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
lycopene	Citrus sp.	-	beta-carotene	-	?

Organism

Organism	UniProt	Comment	Textmining
Citrus sp.	-	gene Lycb-1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
lycopene	-	Citrus sp.	beta-carotene	-	?

Synonyms

Synonyms	Comment	Organism
LYCB	-	Citrus sp.

General Information

General Information	Comment	Organism
metabolism	key enzyme for the synthesis of beta-carotene	Citrus sp.
physiological function	regulatory effect of Lycb-1 gene on plant carotenoid metabolism and fruit transcriptome, overview	Citrus sp.