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Literature summary for 5.5.1.19 extracted from

  • Hornero-Mendez, D.; Britton, G.
    Involvement of NADPH in the cyclization reaction of carotenoid biosynthesis (2002), FEBS Lett., 515, 133-136.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
NAD(P)H absolutely required for cyclization reaction. No hydrogen is transferred from NADPH, which is therefore not involved directly in the cyclization reaction, but must play an indirect role, e.g. as an allosteric activator Pantoea ananatis

Organism

Organism UniProt Comment Textmining
Pantoea ananatis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Pantoea ananatis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lycopene the hydrogen atom introduced at C(2) in the cyclization comes from water and not from NADPH. The mechanism involves the initiation of cyclization by H+ attack at C(2) of the folded acyclic end group of the precursor Pantoea ananatis beta-carotene
-
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Synonyms

Synonyms Comment Organism
CrtY
-
Pantoea ananatis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Pantoea ananatis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
assay at Pantoea ananatis