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Literature summary for 5.5.1.12 extracted from

  • Peters, R.J.; Croteau, R.B.
    Abietadiene synthase catalysis: mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement (2002), Proc. Natl. Acad. Sci. USA, 99, 580-584.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Abies grandis

Protein Variants

Protein Variants Comment Organism
D621A
-
Abies grandis
D625A no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis
D766A no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis
D845A no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis
E589A no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis
E699A no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis
E773A no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis
E778A no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis
N765A no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis
R584A no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis
R586A no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis
R762A no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis
S721A no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis
T617A no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis
T769A no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis
T848A no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis
Y841F no effect on geranylgeranyl diphosphate reaction, but lower turnover with copalyl diphosphate than wild-type Abies grandis

Inhibitors

Inhibitors Comment Organism Structure
(13alpha)-N,13-dimethylpodocarp-8(14)-en-13-aminium chloride
-
Abies grandis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate Abies grandis
-
(+)-copalyl diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Abies grandis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate
-
Abies grandis (+)-copalyl diphosphate
-
?