Application | Comment | Organism |
---|---|---|
drug development | since the enzyme is not present in mammals, it is a promising target for the design of drugs to treat the Chagas' disease caused by Trypanosoma cruzi in humans | Trypanosoma cruzi |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-alpha-D-galactopyranose | Trypanosoma cruzi | - |
UDP-alpha-D-galactofuranose | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose | quantum mechanics-molecular mechanics (QM/MM) molecular dynamics study and reaction mechanism, characterization of the structures of reactants, products, intermediate species and transitions states, overview | Trypanosoma cruzi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-alpha-D-galactopyranose | - |
Trypanosoma cruzi | UDP-alpha-D-galactofuranose | - |
r | |
UDP-alpha-D-galactopyranose | via iminium ion intermediates | Trypanosoma cruzi | UDP-alpha-D-galactofuranose | - |
r |
Synonyms | Comment | Organism |
---|---|---|
TcUGM | - |
Trypanosoma cruzi |
UGM | - |
Trypanosoma cruzi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | involved in the catalyzed reaction, formation of a flavin-substrate/flavin-product adduct | Trypanosoma cruzi |
General Information | Comment | Organism |
---|---|---|
additional information | enzyme TcUGM active site structure, overview | Trypanosoma cruzi |
physiological function | the enzyme UDP-galactopyranose mutase (UGM) catalyses the conversion of galactopyranose into galactofuranose. It is critical for the survival and proliferation of several pathogenic agents, both prokaryotic and eukaryotic | Trypanosoma cruzi |