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Literature summary for 5.4.99.9 extracted from

  • Pierdominici-Sottile, G.; Cossio Perez, R.; Galindo, J.F.; Palma, J.
    QM/MM molecular dynamics study of the galactopyranose -> galactofuranose reaction catalysed by Trypanosoma cruzi UDP-galactopyranose mutase (2014), PLoS ONE, 9, e109559 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development since the enzyme is not present in mammals, it is a promising target for the design of drugs to treat the Chagas' disease caused by Trypanosoma cruzi in humans Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-galactopyranose Trypanosoma cruzi
-
UDP-alpha-D-galactofuranose
-
r

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Reaction

Reaction Comment Organism Reaction ID
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose quantum mechanics-molecular mechanics (QM/MM) molecular dynamics study and reaction mechanism, characterization of the structures of reactants, products, intermediate species and transitions states, overview Trypanosoma cruzi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-galactopyranose
-
Trypanosoma cruzi UDP-alpha-D-galactofuranose
-
r
UDP-alpha-D-galactopyranose via iminium ion intermediates Trypanosoma cruzi UDP-alpha-D-galactofuranose
-
r

Synonyms

Synonyms Comment Organism
TcUGM
-
Trypanosoma cruzi
UGM
-
Trypanosoma cruzi

Cofactor

Cofactor Comment Organism Structure
FAD involved in the catalyzed reaction, formation of a flavin-substrate/flavin-product adduct Trypanosoma cruzi

General Information

General Information Comment Organism
additional information enzyme TcUGM active site structure, overview Trypanosoma cruzi
physiological function the enzyme UDP-galactopyranose mutase (UGM) catalyses the conversion of galactopyranose into galactofuranose. It is critical for the survival and proliferation of several pathogenic agents, both prokaryotic and eukaryotic Trypanosoma cruzi