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Literature summary for 5.4.99.9 extracted from

  • Beverley, S.M.; Owens, K.L.; Showalter, M.; Griffith, C.L.; Doering, T.L.; Jones, V.C.; McNeil, M.R.
    Eukaryotic UDP-galactopyranose mutase (GLF gene) in microbial and metazoal pathogens (2005), Eukaryot. Cell, 4, 1147-1154.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.4.99.9

Application

Application Comment Organism
drug development UGM inhibition may provide an attractive drug target in those eukaryotes where galactofuranose plays a critical role in cellular viability and virulence Caenorhabditis elegans
drug development UGM inhibition may provide an attractive drug target in those eukaryotes where galactofuranose plays a critical role in cellular viability and virulence Cryptococcus neoformans
drug development UGM inhibition may provide an attractive drug target in those eukaryotes where galactofuranose plays a critical role in cellular viability and virulence Leishmania major
drug development UGM inhibition may provide an attractive drug target in those eukaryotes where galactofuranose plays a critical role in cellular viability and virulence Trypanosoma cruzi

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Caenorhabditis elegans
expression in Escherichia coli Cryptococcus neoformans
expression in Escherichia coli Leishmania major
expression in Escherichia coli Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-galactopyranose Caenorhabditis elegans
-
 UDP-galactofuranose
-
 r
UDP-galactopyranose Cryptococcus neoformans
-
 UDP-galactofuranose
-
 r
UDP-galactopyranose Leishmania major
-
 UDP-galactofuranose
-
 r
UDP-galactopyranose Trypanosoma cruzi
-
 UDP-galactofuranose
-
 r

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-
Cryptococcus neoformans Q5KEL8
-
-
Leishmania major Q5EEK0
-
-
Trypanosoma cruzi Q5EEK1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-galactopyranose
-
 Caenorhabditis elegans UDP-galactofuranose
-
 r
UDP-galactopyranose
-
 Cryptococcus neoformans UDP-galactofuranose
-
 r
UDP-galactopyranose
-
 Leishmania major UDP-galactofuranose
-
 r
UDP-galactopyranose
-
 Trypanosoma cruzi UDP-galactofuranose
-
 r
UDP-galactopyranose pH 7.1, 30°C Caenorhabditis elegans UDP-galactofuranose
-
 r
UDP-galactopyranose pH 7.1, 30°C Cryptococcus neoformans UDP-galactofuranose
-
 r
UDP-galactopyranose pH 7.1, 30°C Leishmania major UDP-galactofuranose
-
 r
UDP-galactopyranose pH 7.1, 30°C Trypanosoma cruzi UDP-galactofuranose
-
 r

Synonyms

Synonyms Comment Organism
GLF gene product
-
 Caenorhabditis elegans
GLF gene product
-
 Cryptococcus neoformans
GLF gene product
-
 Leishmania major
GLF gene product
-
 Trypanosoma cruzi
UDP-galactopyranose mutase
-
 Caenorhabditis elegans
UDP-galactopyranose mutase
-
 Cryptococcus neoformans
UDP-galactopyranose mutase
-
 Leishmania major
UDP-galactopyranose mutase
-
 Trypanosoma cruzi
UGM
-
 Caenorhabditis elegans
UGM
-
 Cryptococcus neoformans
UGM
-
 Leishmania major
UGM
-
 Trypanosoma cruzi

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Caenorhabditis elegans
FAD
-
 Cryptococcus neoformans
FAD
-
 Leishmania major
FAD
-
 Trypanosoma cruzi