BRENDA - Enzyme Database
show all sequences of 5.4.99.8

Cloning and molecular analysis of cDNA encoding cycloartenol synthase from Centella asiatica (L.) urban

Kim, O.T.; Kim, M.Y.; Hwang, S.J.; Ahn, J.C.; Hwang, B.; Biotechnol. Bioprocess Eng. 10, 16-22 (2005)
No PubMed abstract available

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expression in DH5-alpha Escherichia coli competent cells
Centella asiatica
Inhibitors
Inhibitors
Commentary
Organism
Structure
methyl jasmonate
inhibits CaCYS transcription
Centella asiatica
additional information
addition of thidiazuron to methyl jasmonate treated smples, sustains mRNA expression
Centella asiatica
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
86300
-
calculated from amino acid sequence
Centella asiatica
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
(S)-2,3-Epoxysqualene
Centella asiatica
-
Cycloartenol
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Centella asiatica
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
leaf
-
Centella asiatica
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
(S)-2,3-Epoxysqualene
-
661372
Centella asiatica
Cycloartenol
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
CaCYS
-
Centella asiatica
cycloartenol synthase
-
Centella asiatica
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in DH5-alpha Escherichia coli competent cells
Centella asiatica
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
methyl jasmonate
inhibits CaCYS transcription
Centella asiatica
additional information
addition of thidiazuron to methyl jasmonate treated smples, sustains mRNA expression
Centella asiatica
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
86300
-
calculated from amino acid sequence
Centella asiatica
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
(S)-2,3-Epoxysqualene
Centella asiatica
-
Cycloartenol
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
leaf
-
Centella asiatica
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
(S)-2,3-Epoxysqualene
-
661372
Centella asiatica
Cycloartenol
-
-
-
?
Other publictions for EC 5.4.99.8
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746683
Zhao
Cloning and characterization ...
Siraitia grosvenorii
Acta Pharm. Sin. B
7
215-222
2017
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2
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747979
Jin
Two cycloartenol synthases fo ...
Polygala tenuifolia
Int. J. Mol. Sci.
18
2426-2437
2017
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1
2
4
2
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748718
Yang
Strengthening triterpene sapo ...
Panax notoginseng
Molecules
22
581-592
2017
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2
2
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749078
Mishra
RNAi and homologous overexpre ...
Withania somnifera
PLoS ONE
11
e0149691
2016
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1
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1
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5
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1
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2
2
2
2
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749096
Calegario
Cloning and functional charac ...
Laurencia dendroidea
PLoS ONE
11
e0165954
2016
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1
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7
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3
3
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748519
Gas-Pascual
Inhibition of cycloartenol sy ...
Nicotiana tabacum
Lipids
50
773-784
2015
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1
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2
1
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727980
Dhar
Cloning and functional charact ...
Withania somnifera, Withania somnifera WS-Y-08
J. Biol. Chem.
289
17249-17267
2014
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1
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6
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2
1
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749137
Gas-Pascual
Plant oxidosqualene metabolis ...
Nicotiana benthamiana, Nicotiana tabacum
PLoS ONE
9
e109156-64
2014
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2
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2
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8
8
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716421
Ito
Triterpene cyclases from Oryza ...
Oryza sativa
Org. Lett.
13
2678-2681
2011
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715543
Wang
Cloning and characterization o ...
Kalanchoe daigremontiana
J. Biol. Chem.
285
29703-29712
2010
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1
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694920
Ohyama
Dual biosynthetic pathways to ...
Arabidopsis thaliana
Proc. Natl. Acad. Sci. USA
106
725-730
2009
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706203
Kim
-
Upregulation of ginsenoside an ...
Panax ginseng
Plant Cell Tissue Organ Cult.
98
25-33
2009
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706246
Liang
-
Antisense suppression of cyclo ...
Panax ginseng
Plant Mol. Biol. Rep.
27
298-304
2009
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2
2
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692358
Shinozaki
Squalene cyclase and oxidosqua ...
Adiantum capillus-veneris
FEBS Lett.
582
310-318
2008
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1
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6
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694886
Babiychuk
Allelic mutant series reveal d ...
Arabidopsis thaliana
Proc. Natl. Acad. Sci. USA
105
3163-3168
2008
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694930
Hu
-
Jasmonic acid mediates gene tr ...
Panax notoginseng
Process Biochem.
43
113-118
2008
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678797
Basyuni
Cloning and functional express ...
Kandelia candel, Rhizophora stylosa
Biosci. Biotechnol. Biochem.
71
1788-1792
2007
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2
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677804
Kolesnikova
Lanosterol biosynthesis in pla ...
Arabidopsis thaliana
Arch. Biochem. Biophys.
447
87-95
2006
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1
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7
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677806
Guhling
Cloning and characterization o ...
Ricinus communis
Arch. Biochem. Biophys.
448
60-72
2006
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682344
Sawai
Plant lanosterol synthase: div ...
Lotus japonicus
Plant Cell Physiol.
47
673-677
2006
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682450
Sawai
-
Functional and structural anal ...
Lotus japonicus
Plant Sci.
170
247-257
2006
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661372
Kim
-
Cloning and molecular analysis ...
Centella asiatica
Biotechnol. Bioprocess Eng.
10
16-22
2005
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1
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2
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661939
Lodeiro
Enzyme redesign: two mutations ...
Arabidopsis thaliana
J. Am. Chem. Soc.
127
14132-14133
2005
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1
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9
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9
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661302
Hayashi
Differential expression of thr ...
Glycyrrhiza glabra
Biol. Pharm. Bull.
27
1086-1092
2004
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1
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3
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