Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.4.99.7 extracted from

  • Dang, H.; Liu, Y.; Pang, W.; Wang, N.; Shyy, J.Y.; Zhu, Y.
    Suppression of 2,3-oxidosqualene cyclase by high-fat diet contributes to liver X receptor-alpha -mediated improvement of hepatic lipid profile (2009), J. Biol. Chem., 284, 6218-6226.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
cholesterol an increased cholesterol level suppresses the expression of 2,3-oxidosqualene cyclase Mus musculus
cholesterol an increased cholesterol level suppresses the expression of 2,3-oxidosqualene cyclase Rattus norvegicus
additional information a high fat diet reduces OSC expression in the liver Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Mus musculus
-
-
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Rattus norvegicus
-
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-2,3-oxidosqualene
-
Mus musculus lanosterol
-
?
(S)-2,3-oxidosqualene
-
Rattus norvegicus lanosterol
-
?
2,3:22,23-diepoxysqualene
-
Mus musculus 24(S),25-epoxylanosterol
-
?
2,3:22,23-diepoxysqualene
-
Rattus norvegicus 24(S),25-epoxylanosterol
-
?

Synonyms

Synonyms Comment Organism
2,3-Oxidosqualene cyclase
-
Mus musculus
2,3-Oxidosqualene cyclase
-
Rattus norvegicus
OSC
-
Mus musculus
OSC
-
Rattus norvegicus