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Literature summary for 5.4.99.7 extracted from

  • Huff, M.W.; Telford, D.E.
    Lord of the rings--the mechanism for oxidosqualene:lanosterol cyclase becomes crystal clear (2005), Trends Pharmacol. Sci., 26, 335-340.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme represents a novel target for treatment of hypercholesterolemia and atherosclerosis Homo sapiens
drug development the enzyme represents a novel target for treatment of hypercholesterolemia and atherosclerosis Sus scrofa

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Homo sapiens
-
Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
RO0717625
-
Sus scrofa
trans-N-(4-(5-[ethyl-(2-hydroxy-ethyl)-amino]-pentyl)-cyclohexyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide fumarate RO0714565 Homo sapiens
[4'-(6-allyl-methyl-amino-hexyloxy)-2'-fluoro-phenyl]-(4-bromo-phenyl)-methanone fumarate RO0488071 Homo sapiens
[4'-(6-allyl-methyl-amino-hexyloxy)-2'-fluoro-phenyl]-(4-bromo-phenyl)-methanone fumarate RO0488071 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3-monoepoxysqualene Homo sapiens
-
lanosterol
-
?
2,3-monoepoxysqualene Sus scrofa
-
lanosterol
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
Göttingen minipig
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-monoepoxysqualene
-
Homo sapiens lanosterol
-
?
2,3-monoepoxysqualene
-
Sus scrofa lanosterol
-
?
2,3:22,23-diepoxysqualene this reaction is enhanced when OSC is inhibited Homo sapiens 24(S),25-epoxylanosterol
-
?
2,3:22,23-diepoxysqualene this reaction is enhanced when OSC is inhibited Sus scrofa 24(S),25-epoxylanosterol
-
?

Subunits

Subunits Comment Organism
monomer crystal analysis Homo sapiens
monomer crystal analysis Sus scrofa

Synonyms

Synonyms Comment Organism
OSC
-
Homo sapiens
OSC
-
Sus scrofa
oxidosqualene:lanosterol cyclase
-
Homo sapiens
oxidosqualene:lanosterol cyclase
-
Sus scrofa