Application | Comment | Organism |
---|---|---|
drug development | the enzyme represents a novel target for treatment of hypercholesterolemia and atherosclerosis | Homo sapiens |
drug development | the enzyme represents a novel target for treatment of hypercholesterolemia and atherosclerosis | Sus scrofa |
Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
RO0717625 | - |
Sus scrofa | |
trans-N-(4-(5-[ethyl-(2-hydroxy-ethyl)-amino]-pentyl)-cyclohexyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide fumarate | RO0714565 | Homo sapiens | |
[4'-(6-allyl-methyl-amino-hexyloxy)-2'-fluoro-phenyl]-(4-bromo-phenyl)-methanone fumarate | RO0488071 | Homo sapiens | |
[4'-(6-allyl-methyl-amino-hexyloxy)-2'-fluoro-phenyl]-(4-bromo-phenyl)-methanone fumarate | RO0488071 | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-monoepoxysqualene | Homo sapiens | - |
lanosterol | - |
? | |
2,3-monoepoxysqualene | Sus scrofa | - |
lanosterol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Sus scrofa | - |
Göttingen minipig | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-monoepoxysqualene | - |
Homo sapiens | lanosterol | - |
? | |
2,3-monoepoxysqualene | - |
Sus scrofa | lanosterol | - |
? | |
2,3:22,23-diepoxysqualene | this reaction is enhanced when OSC is inhibited | Homo sapiens | 24(S),25-epoxylanosterol | - |
? | |
2,3:22,23-diepoxysqualene | this reaction is enhanced when OSC is inhibited | Sus scrofa | 24(S),25-epoxylanosterol | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | crystal analysis | Homo sapiens |
monomer | crystal analysis | Sus scrofa |
Synonyms | Comment | Organism |
---|---|---|
OSC | - |
Homo sapiens |
OSC | - |
Sus scrofa |
oxidosqualene:lanosterol cyclase | - |
Homo sapiens |
oxidosqualene:lanosterol cyclase | - |
Sus scrofa |