Application | Comment | Organism |
---|---|---|
medicine | target for the development of new hypocjolesterolemic drugs | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Pichia pastoris | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
hanging-drop vapor-diffusion method | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ro 48-8071 | IC50: 8.0 nM for the recombinant enzyme, IC50: 6.5 nM for the human liver enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | monotopic, integral membrane protein | Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
80000 | - |
1 * 80000, SDS-PAGE | Homo sapiens |
86000 | - |
equilibrium sedimentation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-2,3-epoxysqualene | Homo sapiens | formation of lanosterol the first sterol precursor of cholesterol in mammals | lanosterol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | the protein is neither glycosylated nor modified post-translationally | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Storage Stability | Organism |
---|---|
-80°C, 10% glycerol, stable for at least 1 year | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-2,3-epoxysqualene | - |
Homo sapiens | lanosterol | - |
? | |
(S)-2,3-epoxysqualene | formation of lanosterol the first sterol precursor of cholesterol in mammals | Homo sapiens | lanosterol | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 80000, SDS-PAGE | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000065 | - |
IC50: 6.5 nM for the human liver enzyme | Homo sapiens | Ro 48-8071 | |
0.000008 | - |
IC50: 8.0 nM for the recombinant enzyme | Homo sapiens | Ro 48-8071 |