Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diethyl dicarbonate | maximal inactivation at neutral pH, ´reactivation by hydroxylamine | Bos taurus | |
N,N-dimethyl-N-(4-methylenebenzophenonyl)amine | IC50: 0.005 mM | Bos taurus | |
N-(2-methylenebenzophenonyl)pyridinium | IC50: 0.059 mM | Bos taurus | |
N-(3-methylenebenzophenonyl)pyridinium bromide | IC50: 0.016 mM | Bos taurus | |
N-(4-methylenebenzophenonyl)pyridinium bromide | IC50: 0.00079 mM | Bos taurus | |
Ro48-8071 | IC50: 22 nM | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.011 | - |
(3S)-2,3-oxidosqualene | - |
Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Bos taurus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
70000 | - |
2 * 70000, SDS-PAGE | Bos taurus |
140000 | - |
non-denaturing PAGE | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.747 | - |
- |
Bos taurus |
Storage Stability | Organism |
---|---|
-20°C or -80°C, phosphate buffer, in presence of Triton and DTT, stable for up to 6 months | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(3S)-2,3-oxidosqualene | two essential histidine residues per active site are necessary for complete activity | Bos taurus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 70000, SDS-PAGE | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
OSC | - |
Bos taurus |
Oxidosqualene-lanosterol cyclase | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Bos taurus |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | 50 | optimal activity between 25°C and 50°C with a maximum at 37°C | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
- |
Bos taurus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 9 | pH 6.0: about 20% of maximal activity, pH 7.0: about 90% of maximal activity, pH 9.0: about 50% of maximal activity | Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000022 | - |
IC50: 22 nM | Bos taurus | Ro48-8071 | |
0.00079 | - |
IC50: 0.00079 mM | Bos taurus | N-(4-methylenebenzophenonyl)pyridinium bromide | |
0.005 | - |
IC50: 0.005 mM | Bos taurus | N,N-dimethyl-N-(4-methylenebenzophenonyl)amine | |
0.016 | - |
IC50: 0.016 mM | Bos taurus | N-(3-methylenebenzophenonyl)pyridinium bromide | |
0.059 | - |
IC50: 0.059 mM | Bos taurus | N-(2-methylenebenzophenonyl)pyridinium |