Literature summary for 5.4.99.7 extracted from

Stach, D.; Zheng, Y.F.; Perez, A.L.; Oehlschlager, A.C.; Abe, I.; Prestwich, G.D.; Hartman, P.G.
Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase (1997), J. Med. Chem., 40, 201-209.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Sulfur-substituted squalene oxide analogues	mechanism-based inhibition	Candida albicans
Sulfur-substituted squalene oxide analogues	mechanism-based inhibition	Rattus norvegicus
Sulfur-substituted squalene oxide analogues	mechanism-based inhibition	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	-	-
Rattus norvegicus	-	-	-
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-
liver	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-squalene-2,3-epoxide	-	Rattus norvegicus	Lanosterol	-	?
(S)-squalene-2,3-epoxide	-	Sus scrofa	Lanosterol	-	?
(S)-squalene-2,3-epoxide	-	Candida albicans	Lanosterol	-	?

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Release 2023.1 (January 2023)