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Literature summary for 5.4.99.5 extracted from

  • Prakash, P.; Aruna, B.; Sardesai, A.A.; Hasnain, S.E.
    Purified recombinant hypothetical protein coded by open reading frame Rv1885c of Mycobacterium tuberculosis exhibits a monofunctional AroQ class of periplasmic chorismate mutase activity (2005), J. Biol. Chem., 280, 19641-19648.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
additional information the enzyme is greatly inhibited at acidic pH. L-phenylalanine, L-tyrosine, and L-tryptophan moderately enhance activity at low concentrations, but they inhibit the enzyme at higher concentrations Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2
-
chorismate
-
Mycobacterium tuberculosis
5
-
chorismate
-
Mycobacterium tuberculosis

Localization

Localization Comment Organism GeneOntology No. Textmining
periplasm
-
Mycobacterium tuberculosis
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
22000
-
monomer, SDS-PAGE Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Chorismate Mycobacterium tuberculosis
-
Prephenate
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
recombinant protein coded by the open reading frame Rv0948
-
Mycobacterium tuberculosis
-
recombinant protein coded by the open reading frame Rv1885c
-

Purification (Commentary)

Purification (Comment) Organism
to near homogeneity Mycobacterium tuberculosis

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2
-
-
Mycobacterium tuberculosis
74
-
-
Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Chorismate
-
Mycobacterium tuberculosis Prephenate
-
?

Subunits

Subunits Comment Organism
dimer 2 * 22000, gel filtration, SDS-PAGE Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
chorismate mutase
-
Mycobacterium tuberculosis

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
37 50 maximally active in this range Mycobacterium tuberculosis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
complete denaturation of the enzyme occurs at a temperature close to 60°C Mycobacterium tuberculosis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
26
-
chorismate
-
Mycobacterium tuberculosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Mycobacterium tuberculosis

pH Range

pH Minimum pH Maximum Comment Organism
6 8.5
-
Mycobacterium tuberculosis