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Literature summary for 5.4.99.5 extracted from

  • Qamra, R.; Prakash, P.; Aruna, B.; Hasnain, S.E.; Mande, S.C.
    Crystallization and preliminary x-ray crystallographic studies of Mycobacterium tuberculosis chorismate mutase (2005), Acta Crystallogr. Sect. F, F61, 473-475.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
drug development the enzyme serves as a potential target for the development of inhibitors specific to the pathogen Mycobacterium tuberculosis

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 (DE3) Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
analysis reveals the presence of two monomers in the asymmetric unit Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
L-tryptophan allosteric inhibitor Mycobacterium tuberculosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
22000
-
 monomer, SDS-PAGE Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Chorismate Mycobacterium tuberculosis
-
 Prephenate
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Chorismate
-
 Mycobacterium tuberculosis Prephenate
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
chorismate mutase
-
 Mycobacterium tuberculosis