Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(Z)-glutaconate | mechanism-based inactivation. Inhibitor induces homolysis of the Co-C bond of coenzyme B12 to afford cob(II)alamin and the 5'-deoxyadenosyl radical. The 5'-deoxyadenosyl radical adds to the double bond of (Z)-glutaconate to afford a radical adduct and subsequent formation of aquocobalamin | Eubacterium barkeri | |
buta-1,3-diene-2,3-dicarboxylate | mechanism-based inactivation. Inhibitor induces homolysis of the Co-C bond of coenzyme B12 to afford cob(II)alamin and the 5'-deoxyadenosyl radical. The 5'-deoxyadenosyl radical adds to a double bond of buta-1,3-diene-2,3-dicarboxylate to afford a relatively stable radical adduct in the active site of the enzyme | Eubacterium barkeri |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Eubacterium barkeri | - |
- |
- |