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Literature summary for 5.4.99.28 extracted from

  • Raychaudhuri, S.; Niu, L.; Conrad, J.; Lane, B.G.; Ofengand, J.
    Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA (1999), J. Biol. Chem., 274, 18880-18886.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tRNA uridine32 Escherichia coli RluA is the only synthase for formation of pseudouridine746 in 23S tRNA tRNA pseudouridine32
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P0AA37
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tRNA uridine32
-
 Escherichia coli tRNA pseudouridine32
-
 ?
tRNA uridine32 RluA is the only synthase for formation of pseudouridine746 in 23S tRNA Escherichia coli tRNA pseudouridine32
-
 ?

Synonyms

Synonyms Comment Organism
RluA
-
 Escherichia coli

General Information

General Information Comment Organism
malfunction the rluA deletion mutant fails to form either 23S RNA pseudouridine746 or tRNA pseudouridine32. Replacement of rluA in trans on a rescue plasmid restores both pseudouridines. There is no difference in exponential growth rate between wild-type and MG1655(rluA-) either in rich or minimal medium at 24, 37, or 42°C, but when both strains are grown together, a strong selection against the deletion strain is observed Escherichia coli