Literature summary for 5.4.99.2 extracted from

de la Fuente, J.; Gortazar, C.; Vicente, J.; Villar, M.
Host expression of methylmalonyl-CoA mutase and tuberculosis: a missing link? (2011), Med. Hypotheses, 76, 361-364.

Search for more literature for 5.4.99.2

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(R)-2-methylmalonyl-CoA	-	Sus scrofa	succinyl-CoA	-	?

Synonyms

Synonyms	Comment	Organism
MCM	-	Sus scrofa

Cofactor

Cofactor	Comment	Organism	Structure
adenosylcobalamin	-	Sus scrofa

General Information

General Information	Comment	Organism
physiological function	methylmalonyl-CoA mutase (MUT) expression influences the risk of acquiring Mycobacterium bovis infection and developing bovine tuberculosis. Genetically-defined higher host MUT expression levels result in lower serum cholesterol concentration and tissue deposits that increase the protective immune response to Mycobacterium bovis, thus resulting in resistance to bovine tuberculosis and better response to Mycobacterium bovis bacilli Calmette-Guerin vaccination	Sus scrofa

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Release 2023.1 (January 2023)