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Literature summary for 5.4.99.18 extracted from

  • Kim, A.; Wolf, N.; Zhu, T.; Johnson, M.; Deng, J.; Cook, J.; Fung, L.
    Identification of Bacillus anthracis PurE inhibitors with antimicrobial activity (2015), Bioorg. Med. Chem., 23, 1492-1499 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
recombinant enzyme expression Bacillus anthracis

Inhibitors

Inhibitors Comment Organism Structure
3-chloro-N-(5-(2,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl)benzamide 19% inhibition at 0.010 mM Bacillus anthracis
4-benzoyl-N-(5-(2,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl)benzamide 13% inhibition at 0.010 mM Bacillus anthracis
4-Nitro-5-aminoimidazole ribonucleotide NAIR Bacillus anthracis
Ciprofloxacin
-
Bacillus anthracis
linezolid
-
Bacillus anthracis
additional information high-throughput screening of compounds binding to Bacillus anthracis PurE. A a low ionic strength buffer condition is used to accentuate the thermal shift stabilization induced by compound binding to Bacillus anthracis PurE. Computational ligand docking to the active site. Determination of inhibitory compounds for inhibition of BaPurE activity and for cytotoxicity against Bacillus anthracis (DELTAANR strain), Escherichia coli (BW25113 strain, wild-type and DELTATolC), Francisella tularensis, Staphylococcus aureus (both methicillin susceptible and methicillin-resistant strains) and Yersinia pestis. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values, overview Bacillus anthracis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
149000
-
gel filtration Bacillus anthracis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole Bacillus anthracis
-
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
-
r

Organism

Organism UniProt Comment Textmining
Bacillus anthracis A0A150QXP6
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme to over 85% purity Bacillus anthracis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
-
Bacillus anthracis 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
-
r

Subunits

Subunits Comment Organism
octamer 8 * 17322, mass spectrometry, 8 * 17323, sequence calculation Bacillus anthracis

Synonyms

Synonyms Comment Organism
N5-CAIR mutase
-
Bacillus anthracis
N5-carboxy-amino-imidazole ribonucleotide mutase
-
Bacillus anthracis
PurE
-
Bacillus anthracis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
20
-
assay at Bacillus anthracis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Bacillus anthracis