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Literature summary for 5.4.99.15 extracted from

  • Carpinelli, J.; Kraemer, R.; Agosin, E.
    Metabolic engineering of Corynebacterium glutamicum for trehalose overproduction: role of the TreYZ trehalose biosynthetic pathway (2006), Appl. Environ. Microbiol., 72, 1949-1955.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
synthesis overexpression of the enzyme treY gene and the treY/treZ synthetic operon encoding enzyme and maltooligosyltrehalose trehalohydrolase significantly increases maltooligosyltrehalose synthase activity, the rate-limiting step, and improves the specific productivity and the final titer of trehalose. Furthermore, a strong decrease is noted in glycogen accumulation. Expression of UDP-glucose pyrophosphorylase/maltooligosyltrehalose synthase and UDP-glucose pyrophosphorylase/maltooligosyltrehalose synthase/maltooligosyltrehalose trehalohydrolase synthetic operons shows a partial recovery in the intracellular glycogen levels and a significant improvement in both intra- and extracellular trehalose content Corynebacterium glutamicum

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of enzyme and maltooligosyltrehalose trehalohydrolase alone or with UPD-glucose pyrophosphorylase in a synthetic operon to improve trehalose production in Escherichia coli Corynebacterium glutamicum

Organism

Organism UniProt Comment Textmining
Corynebacterium glutamicum
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