Literature summary for 5.4.99.13 extracted from

Rohwerder, T.; Breuer, U.; Benndorf, D.; Lechner, U.; Mueller, R.H.
The alkyl tert-butyl ether intermediate 2-hydroxyisobutyrate is degraded via a novel cobalamin-dependent mutase pathway (2006), Appl. Environ. Microbiol., 72, 4128-4135.

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Cloned(Commentary)

Cloned (Comment)	Organism
enzyme small subunit	uncultured bacterium

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Co2+	or cobalamin, strictly required. During growth on limiting concentrations of cobalt, strain accumulates 2-hydroxyisobutyrate	uncultured bacterium

Organism

Organism	UniProt	Comment	Textmining
uncultured bacterium	-	isolated from methyl t-butyl ether-contaminated groundwater, able to grow on methyl t-butyl ether and ethyl t-butyl ether as sole carbon sources	-
uncultured bacterium L108	-	isolated from methyl t-butyl ether-contaminated groundwater, able to grow on methyl t-butyl ether and ethyl t-butyl ether as sole carbon sources	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-hydroxyisobutyrate	-	uncultured bacterium	3-hydroxybutyrate	-	?
2-hydroxyisobutyrate	-	uncultured bacterium L108	3-hydroxybutyrate	-	?

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	uncultured bacterium
Cobalamin	-	uncultured bacterium
coenzyme A	-	uncultured bacterium

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Release 2023.1 (January 2023)