Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Synechococcus sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4,5-Dioxovalerate | competitive inhibition of pyridoxamine-phosphate form of the enzyme and mixed-type inhibition of the pyridoxal-phosphate form of the enzyme | Synechococcus sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
4,5-Diaminovalerate | - |
Synechococcus sp. | |
0.067 | - |
(S)-4-Amino-5-oxopentanoate | - |
Synechococcus sp. | |
1.4 | - |
4,5-Dioxovalerate | - |
Synechococcus sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Synechococcus sp. | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-glutamate 1-semialdehyde = 5-aminolevulinate | ping-pong bi-bi mechanism in which 4,5-diaminovalerate is the second substrate and 4,5-dioxovalerate is an alternative first substrate | Synechococcus sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-4-Amino-5-oxopentanoate | - |
Synechococcus sp. | 5-Amino-4-oxopentanoate | - |
? | |
4,5-Diaminovalerate | is a substrate for the pyridoxal 5'-phosphate form of the enzyme | Synechococcus sp. | ? | - |
? | |
4,5-Dioxovalerate | is a substrate for the pyridoxamine form of the enzyme | Synechococcus sp. | 5-Amino-4-oxopentanoate | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.95 | - |
(S)-4-Amino-5-oxopentanoate | - |
Synechococcus sp. |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxamine 5'-phosphate | the pyridoxal-phosphate form of the enzyme and the pyridoxamine-phosphate form of the enzyme are similarly active | Synechococcus sp. |