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Literature summary for 5.4.3.8 extracted from
- Purification and functional characterization of glutamate-1-semialdehyde aminotransferase from Chlamydomonas reinhardtii (1991), J. Biol. Chem., 266, 161-167.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Aminooxyacetate | - |
Chlamydomonas reinhardtii |  |
| gabaculine | - |
Chlamydomonas reinhardtii | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
gel filtration, nondenaturing rate zonal sedimentation on glycerol gradients | Chlamydomonas reinhardtii |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-4-Amino-5-oxopentanoate | Chlamydomonas reinhardtii | formation of 5-aminolevulinic acid, which is the first committed precursor of chlorophyll biosynthesis in the chloroplast | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Chlamydomonas reinhardtii | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Chlamydomonas reinhardtii |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.2 | - |
- |
Chlamydomonas reinhardtii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-4-Amino-5-oxopentanoate | - |
Chlamydomonas reinhardtii | 5-Amino-4-oxopentanoate | - |
? | |
| (S)-4-Amino-5-oxopentanoate | formation of 5-aminolevulinic acid, which is the first committed precursor of chlorophyll biosynthesis in the chloroplast | Chlamydomonas reinhardtii | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 43000, SDS-PAGE | Chlamydomonas reinhardtii |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
- |
Chlamydomonas reinhardtii |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8 | pH 6.5: about 30% of maximal activity, pH 8.0: about 50% of maximal activity | Chlamydomonas reinhardtii |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | required | Chlamydomonas reinhardtii | |
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Release 2023.1 (January 2023)
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