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Literature summary for 5.4.2.8 extracted from

  • Veiga-da-Cunha, M.; Vleugels, W.; Maliekal, P.; Matthijs, G.; Van Schaftingen, E.
    Mammalian phosphomannomutase PMM1 is the brain IMP-sensitive glucose-1,6-bisphosphatase (2008), J. Biol. Chem., 283, 33988-33993.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells and HEK-293T cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
IMP IMP stimulates by more than 100fold the intrinsic glucose-1,6-bisphosphatase activity of recombinant PMM1 while inhibiting its phosphoglucomutase activity Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-D-glucose 1,6-bisphosphate
-
 Mus musculus ?
-
 ?
alpha-D-mannose 1-phosphate
-
 Mus musculus alpha-D-mannose 6-phosphate
-
 ?
additional information PMM1 is less specific: it has nearly equal phosphomannomutase and phosphoglucomutase activities as well as a modest glucose-1,6-bisphosphatase activity corresponding to about 3% of its phosphomannomutase activity Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
IMP-sensitive glucose-1,6-bisphosphatase
-
 Mus musculus
phosphomannomutase 1
-
 Mus musculus
PMM1 multifunctional enzyme Mus musculus