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Literature summary for 5.4.2.8 extracted from

  • Guha, S.K.; Rose, Z.B.
    The synthesis of mannose 1-phosphate in brain (1985), Arch. Biochem. Biophys., 243, 168-173.
    View publication on PubMed
Search for more literature for 5.4.2.8

Activating Compound

Activating Compound Comment Organism Structure
alpha-D-glucose 1,6-diphosphate or alpha-D-mannose 1,6-diphosphate required Oryctolagus cuniculus
alpha-D-glucose 1,6-diphosphate Km: 0.0003 mM Oryctolagus cuniculus
alpha-D-Mannose 1,6-diphosphate Km: 0.0003 mM Oryctolagus cuniculus
alpha-D-Mannose 1,6-diphosphate or alpha-D-glucose 1,6-diphosphate required Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
2-deoxyglucose 6-phosphate
-
 Oryctolagus cuniculus
glucose 6-phosphate poor, competitive with respect to mannose 6-phosphate Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.016
-
 mannose 1-phosphate in presence of glucose 1,6-diphosphate Oryctolagus cuniculus
0.022
-
 glucose 1-phosphate
-
 Oryctolagus cuniculus
0.074
-
 mannose 6-phosphate in presence of glucose 1,6-diphosphate Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ divalent cation required, at 2.0 mM 57% of the activation relative to Mg2+ Oryctolagus cuniculus
Mg2+ divalent cation required, Mg2+ is most effective Oryctolagus cuniculus
Mg2+ maximal activation at 2.0 mM Oryctolagus cuniculus
Mn2+ divalent cation required, at 2.0 mM 7% of the activation relative to Mg2+ Oryctolagus cuniculus
Ni2+ divalent cation required, at 2.0 mM 22% of the activation relative to Mg2+ Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-mannose 6-phosphate Oryctolagus cuniculus the enzyme produces mannose 1-phosphate for the synthesis of mannose-1,6-diphosphate as well as of GDPmannose D-mannose 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Mannose 1-phosphate r Oryctolagus cuniculus D-Mannose 6-phosphate
-
 ?
D-mannose 6-phosphate the enzyme produces mannose 1-phosphate for the synthesis of mannose-1,6-diphosphate as well as of GDPmannose Oryctolagus cuniculus D-mannose 1-phosphate
-
 ?
Glucose 1-phosphate
-
 Oryctolagus cuniculus Glucose 6-phosphate
-
 ?