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Literature summary for 5.4.2.4 extracted from

  • Oslund, R.C.; Su, X.; Haugbro, M.; Kee, J.M.; Esposito, M.; David, Y.; Wang, B.; Ge, E.; Perlman, D.H.; Kang, Y.; Muir, T.W.; Rabinowitz, J.D.
    Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate (2017), Nat. Chem. Biol., 13, 1081-1087 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-phospho-D-glyceroyl phosphate Homo sapiens
-
 2,3-bisphospho-D-glycerate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
4T1 cell
-
 Homo sapiens
-
A-431 cell
-
 Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-phospho-D-glyceroyl phosphate
-
 Homo sapiens 2,3-bisphospho-D-glycerate
-
 ?

Synonyms

Synonyms Comment Organism
BPGM
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme deletion disrupts PGAM1 activity and results in higher serine de novo synthesis flux Homo sapiens
metabolism the enzyme primarily impacts 3-phosphoglycerate concentration and thereby serine pathway flux Homo sapiens