Activating Compound | Comment | Organism | Structure |
---|---|---|---|
alpha-D-Glucose 1,6-bisphosphate | dependent on | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 and Rosetta(DE3) cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
T556A | the mutant shows about wild type activity | Homo sapiens |
T556E | the mutant shows about wild type activity | Homo sapiens |
T559A | the mutant shows about wild type activity | Homo sapiens |
T559E | the mutant shows about wild type activity | Homo sapiens |
T562A | the mutant shows slightly reduced activity compared to the wild type enzyme | Homo sapiens |
T562E | the mutant shows strongly reduced activity compared to the wild type enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme with a C-terminus 6xHis tag completely loses activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-D-glucose 1-phosphate | Homo sapiens | - |
D-glucose 6-phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P36871 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA agarose column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-D-glucose 1-phosphate | - |
Homo sapiens | D-glucose 6-phosphate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
PGM1 | - |
Homo sapiens |
phosphoglucomutase1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme depletion is associated with declined cellular glycogen content and decreased rates of glycogenolysis and glycogenesis. Furthermore, enzyme depletion suppresses cell proliferation under long-term repetitive glucose depletion | Homo sapiens |
physiological function | the enzyme is necessary for sustained cell growth under repetitive glucose depletion | Homo sapiens |