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Literature summary for 5.4.2.2 extracted from
- Phosphoglucomutase (1962), The Enzymes, 2nd Ed (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. ), 6, 161-178.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| alpha-D-glucose 1,6-diphosphate | - |
Saccharomyces cerevisiae |  |
| alpha-D-glucose 1,6-diphosphate | the beta-form is inactive | Oryctolagus cuniculus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ag+ | - |
Oryctolagus cuniculus | |
| Cu2+ | - |
Oryctolagus cuniculus | |
| F- | - |
Oryctolagus cuniculus | |
| Hg2+ | - |
Oryctolagus cuniculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Glucose 6-phosphate | Oryctolagus cuniculus | synthesis of glucose 1-phosphate for the formation of UDPglucose | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
rabbit | - |
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Oryctolagus cuniculus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| alpha-D-glucose 1-phosphate = D-glucose 6-phosphate | in the forward reaction a phosphate from the enzyme is transferred to C-6 of glucose 1-phosphate which results in a dephosphoenzyme intermediate. In the second step phosphate from the C-1 of glucose is transferred to the enzyme for its regeneration. The reverse reaction proceeds via a similar mechanism | Oryctolagus cuniculus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4-6°C, 0.05 M acetate buffer, pH 5.0, crystalline enzyme form, many months stable | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-D-glucose 1-phosphate | - |
Saccharomyces cerevisiae | alpha-D-glucose 6-phosphate | - |
? | |
| alpha-D-glucose 1-phosphate | the beta-form is inactive | Oryctolagus cuniculus | alpha-D-glucose 6-phosphate | - |
? | |
| Glucose 6-phosphate | - |
Oryctolagus cuniculus | Glucose 1-phosphate | - |
? | |
| Glucose 6-phosphate | synthesis of glucose 1-phosphate for the formation of UDPglucose | Oryctolagus cuniculus | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
purified enzyme in presence of Mg2+ | Oryctolagus cuniculus |
| 7.5 | 9.2 | crude enzyme form | Oryctolagus cuniculus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
unstable above | Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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