Cloned (Comment) | Organism |
---|---|
stable overexpression of thromboxane synthase in SKMES-1 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ozagrel | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate | Homo sapiens | - |
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | an adenocarcinoma cell line | Homo sapiens | - |
non-small cell lung cancer cell | adenocarcinomas and squamous cell carcinomas, enzyme expression profile, overview. Enzyme expression is higher in adenocarcinoma and female patients | Homo sapiens | - |
SK-MES-1 cell | a squamous cell carcinoma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate | - |
Homo sapiens | (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thromboxane synthase | - |
Homo sapiens |
TXS | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition induces cell death in vitro. Selective TXS inhibition significantly reduces tumour cell growth and increases apoptosis, while TXS overexpression stimulates cell proliferation and invasiveness, and is protective against apoptosis, quantification of multi-parameter apoptosis signalling, overview | Homo sapiens |
physiological function | thromboxane synthase metabolises prostaglandin H2 into thromboxanes, which are biologically active on cancer cells. TXS overexpression occurs in a range of cancers, and associated with a poor prognosis, although in non-small lung cancer cells, no significant correlation with patient survival is observed | Homo sapiens |