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Literature summary for 5.3.99.5 extracted from
- Thromboxane synthase and prostacyclin synthase as P-450 enzymes with regard to the mechanisms of PGI2 and TXA2 biosynthesis (1992), Front. Biotransform., 6, 183-199.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CGS 13080 | - |
Homo sapiens |  |
| OKY 1581 | - |
Homo sapiens | |
| UK 37,248 | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Sus scrofa | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Sus scrofa | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate | mechanism | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Homo sapiens | - |
| lung | - |
Sus scrofa | - |
| platelet | - |
Homo sapiens | - |
| platelet | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 15-Ketoprostaglandin H2 | - |
Homo sapiens | ? | - |
? | |
| 2 prostaglandin G2 + H2O | i.e. PGG2 | Homo sapiens | 15-hydroperoxythromboxane B2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid | - |
? | |
| 8-Isoprostaglandin H2 | - |
Homo sapiens | 8-cis-12-Hydroperoxy-5,8,10-heptadecatrienoic acid | - |
? | |
| prostaglandin H1 | - |
Homo sapiens | 12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1 | thromboxane B2 is not mentioned as product | ? | |
| Prostaglandin H2 | i.e. PGH2 | Homo sapiens | thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid | - |
? | |
| Prostaglandin H2 | i.e. PGH2 | Sus scrofa | thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid | - |
? | |
| Prostaglandin H3 | - |
Homo sapiens | Thromboxane B3 + DELTA14-12-hydroperoxy-5,8,10-heptadecatrienoic acid | - |
? | |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | - |
unstable below | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome P450 | - |
Sus scrofa | |
| cytochrome P450 | a cytochrome P450 enzyme | Homo sapiens |
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