Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the extent of prostaglandin I2 production is determined by an appropriate ratio of COX-1/COX-2 to PGIS. Human vascular endothelial cells transfected with a construct that contains COX-1 and prostaglandin-I synthase cDNAs have an equivalent increase in COX-1 and PGIS, and produce a large quantity of prostaglandin-I synthase which is more than 200fold over that produced by untransfected cells | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | overexpression of PGIS is highly effective in controlling vascular diseases and ischemia-reperfusion tissue injury, gene transfer of bicistronic COX-1/PGIS has the potential for treatment of diverse clinical disorders including vascular diseases, pulmonary hypertension, and ischemia-reperfusion cerebral and cardiac injury | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
from endothelilal cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is deactivated by prostaglandin H2 and peroxides | Bos taurus | |
additional information | the enzyme is deactivated by prostaglandin H2 and peroxides | Homo sapiens | |
peroxynitrite | inhibits PGIS activity by nitration of tyrosine 430 | Bos taurus | |
peroxynitrite | inhibits PGIS activity by nitration of Tyr 430 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | anchors to the membrane with a single N-terminal transmembrane domain, the bulk of the enzyme is located at the cytosolic side of ER | Mus musculus | 16020 | - |
membrane | anchors to the membrane with a single N-terminal transmembrane domain, the bulk of the enzyme is located at the cytosolic side of ER | Homo sapiens | 16020 | - |
membrane | anchors to the membrane with a single N-terminal transmembrane domain, the bulk of the enzyme is located at the cytosolic side of ER | Bos taurus | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
52000 | - |
- |
Bos taurus |
56000 | - |
- |
Homo sapiens |
56000 | - |
- |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | Mus musculus | - |
Prostaglandin I2 | - |
? | |
Prostaglandin H2 | Homo sapiens | - |
Prostaglandin I2 | - |
? | |
Prostaglandin H2 | Bos taurus | - |
Prostaglandin I2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Homo sapiens | - |
aorta | - |
Bos taurus | - |
blastocyst | - |
Mus musculus | - |
blood platelet | microsomal fraction | Homo sapiens | - |
blood platelet | microsomal fraction | Bos taurus | - |
embryo | - |
Mus musculus | - |
oviduct | - |
Mus musculus | - |
oviduct | - |
Homo sapiens | - |
vascular endothelial cell | - |
Mus musculus | - |
vascular endothelial cell | - |
Homo sapiens | - |
vascular endothelial cell | - |
Bos taurus | - |
vascular smooth muscle cell | - |
Mus musculus | - |
vascular smooth muscle cell | - |
Homo sapiens | - |
vascular smooth muscle cell | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Mus musculus | Prostaglandin I2 | - |
? | |
Prostaglandin H2 | - |
Homo sapiens | Prostaglandin I2 | - |
? | |
Prostaglandin H2 | - |
Bos taurus | Prostaglandin I2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PGIS | - |
Mus musculus |
PGIS | - |
Homo sapiens |
PGIS | - |
Bos taurus |
prostacyclin synthase | - |
Mus musculus |
prostacyclin synthase | - |
Homo sapiens |
prostacyclin synthase | - |
Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Mus musculus | |
heme | - |
Homo sapiens | |
heme | - |
Bos taurus |