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Literature summary for 5.3.99.4 extracted from

  • Wade, M.L.; Voelkel, N.F.; Fitzpatrick, F.A.
    "Suicide" inactivation of prostaglandin I2 synthase: characterization of mechanism-based inactivation with isolated enzyme and endothelial cells (1995), Arch. Biochem. Biophys., 321, 435-458.
No PubMed abstract available
Search for more literature for 5.3.99.4

Inhibitors

Inhibitors Comment Organism Structure
Prostaglandin H1 slight inactivation Bos taurus
prostaglandin H2 9,11-azoprosta-5,13-dienoic acid prevents inactivation; inactivation originates primarily from a transition-state intermediate, not from malondialdehyde formed by hydrolysis of prostaglandin endoperoxides; rapid inactivation of purified enzyme during incubation with prostaglandin H2 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Bos taurus
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
 Bos taurus Prostaglandin I2 prostaglandin I2 ?