Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | Homo sapiens | - |
Prostaglandin E2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | in brain mPGES-2 is detected in neurons, activated microglia, and endothelium, but not in resting microglia, astrocytes, or smooth muscle cells | Homo sapiens | - |
microglia | mPGES-2 colocalizedswith microglia in activated (amoeboid-shaped) cells | Homo sapiens | - |
middle frontal gyrus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Homo sapiens | Prostaglandin E2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
microsomal prostaglandin E synthase-2 | - |
Homo sapiens |
mPGES-2 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | mPGES-2 immunoreactivity is particularly elevated in the pyramidal neurons of brains from three of five sporadic and four of five familial Alzheimer's disease patients compared with four of five age-matched control brains that showed minimal immunoreactivity | up |