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Literature summary for 5.3.99.3 extracted from

  • Xing, L.; Kurumbail, R.G.; Frazier, R.B.; Davies, M.S.; Fujiwara, H.; Weinberg, R.A.; Gierse, J.K.; Caspers, N.; Carter, J.S.; McDonald, J.J.; Moore, W.M.; Vazquez, M.L.
    Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactions (2009), J. Comput. Aided Mol. Des., 23, 13-24.
    View publication on PubMed
Search for more literature for 5.3.99.3

Cloned(Commentary)

Cloned (Comment) Organism
into the vector pET30 for expression in Escherichia coli BL21Star DE3 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
microsome
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
18000
-
 monomer Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Homo sapiens
-
 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O14684
-
-

Purification (Commentary)

Purification (Comment) Organism
using Ni-NTA affinity and size exclusion chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Homo sapiens (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Subunits

Subunits Comment Organism
homotrimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
microsomal prostaglandin E synthase-1
-
 Homo sapiens
mPGES-1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
glutathione
-
 Homo sapiens