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Literature summary for 5.3.99.3 extracted from

  • Astle, S.; Newton, R.; Thornton, S.; Vatish, M.; Slater, D.M.
    Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour (2007), Mol. Hum. Reprod., 13, 69-75.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
interleukin 1beta stimulates release of prostaglandin E2 by myometrical smooth muscle cells and increases COX-2 and mPGES-1 mRNA and protein expression Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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isoforms mPGES-1 and cPGES
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Homo sapiens Q9H7Z7 isoform mPGES-2
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Source Tissue

Source Tissue Comment Organism Textmining
myometrium isoform mPGES-1 localizes mostly in myometrial and vascular smooth muscle cells of pregnant women. Isoform cPGES is diffusely located throughout the myometrium. Expression of COX-2 and isoform mPGES-1 mRNA with term labour, whereas cPGES expression does not change. Interleukin 1beta stimulates release of prostaglandin E2 by myometrical smooth muscle cells and increases COX-2 and mPGES-1 mRNA and protein expression Homo sapiens
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myometrium isoform mPGES-2 protein is largely in stromal cells surrounding smooth vascular muscle. Expression of mPGES-2 mRNA increases with term labour and preterm labour Homo sapiens
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