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Literature summary for 5.3.99.3 extracted from
- Involvement of early growth response gene 1 in the modulation of microsomal prostaglandin E synthase 1 by epigallocatechin gallate in A549 human pulmonary epithelial cells (2007), Biochem. Pharmacol., 73, 125-135.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| epigallocatechin gallate | enhances COX-2 and isoform mPGES-1 gene expression and production of prostaglandin E2. Induction of mPGES-1 is mediated by active ERK1/2MAP kinases and early growth response gene 1 | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | - |
Homo sapiens | - |
| epithelium | pulmonary epithelial cell | Homo sapiens | - |
| pulmonary artery | pulmonary epithelial cell | Homo sapiens | - |
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Release 2023.1 (January 2023)
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