Literature summary for 5.3.99.3 extracted from

Vazquez-Tello, A.; Fan, L.; Hou, X.; Joyal, J.S.; Mancini, J.A.; Quiniou, C.; Clyman, R.I.; Gobeil, F.Jr.; Varma, D.R.; Chemtob, S.
Intracellular-specific colocalization of prostaglandin E2 synthases and cyclooxygenases in the brain (2004), Am. J. Physiol., 287, R1155-R1163.

Search for more literature for 5.3.99.3

Activating Compound

Activating Compound	Comment	Organism	Structure
glutathione	-	Rattus norvegicus
glutathione	-	Sus scrofa

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C-delta-35	35-amino acid COOH-terminal deletion, diminishes association of the enzyme with membranes	Rattus norvegicus
C-delta-35	35-amino acid COOH-terminal deletion, diminishes association of the enzyme with membranes	Sus scrofa
C58K	diminishes association of the enzyme with membranes	Rattus norvegicus
C58K	diminishes association of the enzyme with membranes	Sus scrofa

Inhibitors

Inhibitors	Comment	Organism	Structure
MK 886	inhibits microsomal PGE2	Rattus norvegicus
MK 886	inhibits microsomal PGE2	Sus scrofa

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-
cytosol	-	Sus scrofa	5829	-
microsome	-	Rattus norvegicus	-	-
microsome	-	Sus scrofa	-	-
nucleus	-	Sus scrofa	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate	Homo sapiens	-	(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate	-	?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate	Rattus norvegicus	-	(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate	-	?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate	Sus scrofa	-	(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
brain	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate	-	Homo sapiens	(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate	-	?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate	-	Rattus norvegicus	(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate	-	?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate	-	Sus scrofa	(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate	-	?
Prostaglandin H2	-	Homo sapiens	Prostaglandin E2	-	?
Prostaglandin H2	-	Rattus norvegicus	Prostaglandin E2	-	?
Prostaglandin H2	-	Sus scrofa	Prostaglandin E2	-	?

Synonyms

Synonyms	Comment	Organism
PGE	-	Homo sapiens
PGE2	-	Rattus norvegicus
PGE2	-	Sus scrofa
Prostaglandin E synthase	-	Homo sapiens
prostaglandin E2 synthase	-	Rattus norvegicus
prostaglandin E2 synthase	-	Sus scrofa

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)