Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
S-nitrosylation | - |
Homo sapiens |
Subunits | Comment | Organism |
---|---|---|
? | x * 55000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ERp57 | - |
Homo sapiens |
ERp72 | - |
Homo sapiens |
PDI | - |
Homo sapiens |
protein disulfide isomerase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is induced during endoplasmic reticulum stress. The enzyme levels are markedly increased in Alzheimer's disease, Parkinson's disease, amyotropic lateral sclerosis and other neurodegenerative diseases | up |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is responsible for the oxidation (formation), reduction (break down) and isomerization (rearrangement) of protein disulfide bonds via disulfide interchange activity. The enzyme also has general chaperone activity | Homo sapiens |