Literature summary for 5.3.4.1 extracted from

Wang, S.B.; Shi, Q.; Xu, Y.; Xie, W.L.; Zhang, J.; Tian, C.; Guo, Y.; Wang, K.; Zhang, B.Y.; Chen, C.; Gao, C.; Dong, X.P.
Protein disulfide isomerase regulates endoplasmic reticulum stress and the apoptotic process during prion infection and PrP mutant-induced cytotoxicity (2012), PLoS ONE, 7, e38221.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Mesocricetus auratus	5829	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
55000	-	x * 55000, SDS-PAGE	Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Insulin-(SS) + GSH	Mesocricetus auratus	-	Insulin-(SH)2 + GSSG	-	?

Organism

Organism	UniProt	Comment	Textmining
Mesocricetus auratus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mesocricetus auratus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Insulin-(SS) + GSH	-	Mesocricetus auratus	Insulin-(SH)2 + GSSG	-	?

Subunits

Subunits	Comment	Organism
?	x * 55000, SDS-PAGE	Mesocricetus auratus

Synonyms

Synonyms	Comment	Organism
DsbA	-	Mesocricetus auratus
Erp	-	Mesocricetus auratus
PDI	-	Mesocricetus auratus
protein disulfide isomerase	-	Mesocricetus auratus

Expression

Organism	Comment	Expression
Mesocricetus auratus	the enzyme is upregulated in prion disease	up

General Information

General Information	Comment	Organism
physiological function	protein disulfide isomerase regulates endoplasmic reticulum stress and the apoptotic process during prion infection and prion protein mutant-induced cytotoxicity. The enzyme functions as a pleiotropic regulator in the processes of different misfolded prion proteins and at different stages during prion infection. The enzyme is involved in mitochondrial dysfunction induced by misfolded prion	Mesocricetus auratus

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Release 2023.1 (January 2023)