Application | Comment | Organism |
---|---|---|
medicine | protein disulfide isomerase upregulation is e.g. associated with cancer, attention-deficite hyperactivity disorder, Alzheimer disease, amyotrophic lateral sclerosis, perinatal asphyxia, brain ischemia, sporadic Creutzfeldt-Jacob disease, major depression, brain injury, tuberous sclerosis, endothelial function, acute coronary syndrome, iscemic heart disease, hepatosteatosis, varioliform gastritis, preeclampsia, obesity, insulin resistance, diabetes, congenital hypothyroid goiter, Helicobacter pylori infection, peridontitis, dehydration, aging, or pregnancy | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | the enzyme is a major calcium binding protein of the endoplasmic reticulum via acidic residues | Homo sapiens | |
Cu+ | the enzyme can bind 10 Cu+/mol and form a tetramer | Homo sapiens | |
Zn2+ | Zn2+ induces dimers/oligomers with decreased isomerase activity | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
x * 55000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Insulin-(SS) + GSH | Homo sapiens | - |
Insulin-(SH)2 + GSSG | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glutathionylation | - |
Homo sapiens |
glycoprotein | O-linked N-acetyl-D-glucosamine | Homo sapiens |
nitrosylation | S-nitrosylation | Homo sapiens |
phosphoprotein | - |
Homo sapiens |
proteolytic modification | - |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Insulin-(SS) + GSH | - |
Homo sapiens | Insulin-(SH)2 + GSSG | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 55000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
AGR2 | - |
Homo sapiens |
ER60 | - |
Homo sapiens |
Erp46 | - |
Homo sapiens |
ERp57 | - |
Homo sapiens |
P5 | - |
Homo sapiens |
PDI | - |
Homo sapiens |
PDIp | - |
Homo sapiens |
protein disulfide isomerase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme silencing prevents Nox responses to angiotensin II and inhibits Akt phosphorylation in vascular cells and parasite phagocytosis in macrophages | Homo sapiens |
physiological function | enzyme overexpression spontaneously enhances Nox activation and expression. In neutrophils, enzyme redox-dependently associates with p47phox and supports the respiratory burst | Homo sapiens |