Cloned (Comment) | Organism |
---|---|
coexpression of wild-type or mutant AGR2 with cysteine-rich regions of MUC2 | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutant Agr2-/- mice lacking AGR2 are viable but are highly susceptible to colitis, the mutant mice show a 3fold reduced Muc2 mRNA level | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | AGR2 is essential for production of intestinal mucin MUC2, but is not required for establishment of intestinal secretory epithelial cell lineages | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestinal epithelium | - |
Mus musculus | - |
intestinal epithelium | intestinal secretory epithelial cell | Mus musculus | - |
intestine | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | AGR2 is essential for production of intestinal mucin MUC2, but is not required for establishment of intestinal secretory epithelial cell lineages | Mus musculus | ? | - |
? | |
additional information | a cysteine residue in the thioredoxin-like domain of AGR2 forms mixed disulfide bonds with MUC2, mutational analysis of the AGR2-MUC2 interaction, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AGR2 | - |
Mus musculus |
anterior gradient homolog 2 | - |
Mus musculus |
More | the enzyme is a member of the PDI enzyme family | Mus musculus |
PDI | - |
Mus musculus |
protein disulfide isomerase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | mice lacking AGR2 are viable but are highly susceptible to colitis, indicating a critical role for AGR2 in protection from disease | Mus musculus |
physiological function | the protein disulfide isomerase AGR2 is essential for production of intestinal mucin MUC2, a large, cysteine-rich glycoprotein that forms the protective mucus gel lining the intestine | Mus musculus |