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Literature summary for 5.3.4.1 extracted from

  • Park, S.W.; Zhen, G.; Verhaeghe, C.; Nakagami, Y.; Nguyenvu, L.T.; Barczak, A.J.; Killeen, N.; Erle, D.J.
    The protein disulfide isomerase AGR2 is essential for production of intestinal mucus (2009), Proc. Natl. Acad. Sci. USA, 106, 6950-6955.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
coexpression of wild-type or mutant AGR2 with cysteine-rich regions of MUC2 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information mutant Agr2-/- mice lacking AGR2 are viable but are highly susceptible to colitis, the mutant mice show a 3fold reduced Muc2 mRNA level Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Mus musculus 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus AGR2 is essential for production of intestinal mucin MUC2, but is not required for establishment of intestinal secretory epithelial cell lineages ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestinal epithelium
-
Mus musculus
-
intestinal epithelium intestinal secretory epithelial cell Mus musculus
-
intestine
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information AGR2 is essential for production of intestinal mucin MUC2, but is not required for establishment of intestinal secretory epithelial cell lineages Mus musculus ?
-
?
additional information a cysteine residue in the thioredoxin-like domain of AGR2 forms mixed disulfide bonds with MUC2, mutational analysis of the AGR2-MUC2 interaction, overview Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
AGR2
-
Mus musculus
anterior gradient homolog 2
-
Mus musculus
More the enzyme is a member of the PDI enzyme family Mus musculus
PDI
-
Mus musculus
protein disulfide isomerase
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Mus musculus

General Information

General Information Comment Organism
malfunction mice lacking AGR2 are viable but are highly susceptible to colitis, indicating a critical role for AGR2 in protection from disease Mus musculus
physiological function the protein disulfide isomerase AGR2 is essential for production of intestinal mucin MUC2, a large, cysteine-rich glycoprotein that forms the protective mucus gel lining the intestine Mus musculus