Literature summary for 5.3.4.1 extracted from

Jain, S.; McGinnes, L.W.; Morrison, T.G.
Overexpression of thiol/disulfide isomerases enhances membrane fusion directed by the Newcastle disease virus fusion protein (2008), J. Virol., 82, 12039-12048.

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Application

Application	Comment	Organism
medicine	overexpression has significant effects on cell-cell fusion mediated by Newcastle disease virus. Overexpression results in increased membrane fusion, and enhanced production of free thiols in Newcastle disease virus fusion protein when expressed without hemagglutinin-neuraminidase protein but drecreased free thiols in Newcastle disease virus fusion protein expressed with hemagglutinin-neuraminidase protein. Overexpression favors a postfusion conformation of surface-expressed Newcastle disease virus fusion protein in the presence of hemagglutinin-neuraminidase protein	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in COS-7 cell	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	overexpression has significant effects on cell-cell fusion mediated by Newcastle disease virus. Overexpression results in increased membrane fusion, and enhanced production of free thiols in Newcastle disease virus fusion protein when expressed without hemagglutinin-neuraminidase protein but drecreased free thiols in Newcastle disease virus fusion protein expressed with hemagglutinin-neuraminidase protein. Overexpression favors a postfusion conformation of surface-expressed Newcastle disease virus fusion protein in the presence of hemagglutinin-neuraminidase protein	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform ERdj5	-
Homo sapiens	-	isoform PDI	-

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Release 2023.1 (January 2023)