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Literature summary for 5.3.4.1 extracted from

  • Liao, M.; Boldbaatar, D.; Gong, H.; Huang, P.; Umemiya, R.; Harnnoi, T.; Zhou, J.; Tanaka, T.; Suzuki, H.; Xuan, X.; Fujisaki, K.
    Functional analysis of protein disulfide isomerases in blood feeding, viability and oocyte development in Haemaphysalis longicornis ticks (2008), Insect Biochem. Mol. Biol., 38, 285-295.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information reduction of gene and protein expression by RNAi has no significant impact by itself. Injection of a combination of isoforms PDI-1/PDI-3 dsRNA has synergistic effects on tick viability. In PDI-1/PDI-3 dsRNA-injected ticks the midgut and cuticle are severely damaged. Disruption of PDI genes leads to a significant reduction of disulfide bond-containing vitellogenin expression in ticks Haemaphysalis longicornis
additional information reduction of gene and protein expression by RNAi impacts tick blood feeding and oviposition. Injection of a combination of isoforms PDI-1/PDI-3 dsRNA has synergistic effects on tick viability. In PDI-1/PDI-3 dsRNA-injected ticks the midgut and cuticle are severely damaged. Disruption of PDI genes leads to a significant reduction of disulfide bond-containing vitellogenin expression in ticks Haemaphysalis longicornis
additional information reduction of gene and protein expression by RNAi impacts tick viability. In PDI-2 dsRNA-injected ticks the midgut and cuticle are severely damaged. Disruption of PDI genes leads to a significant reduction of disulfide bond-containing vitellogenin expression in ticks Haemaphysalis longicornis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Haemaphysalis longicornis protein disulfide isomerases are involved in blood feeding, viability and oocyte development, probably by mediating the formation of disulfide bond-containing proteins of the ticks and the formation of basement membrane and cuticle components such as extracellular matrix ?
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Organism

Organism UniProt Comment Textmining
Haemaphysalis longicornis A5LHV9 isoform Pdi-2
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Haemaphysalis longicornis A5LHW0 isoform Pdi-1
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Haemaphysalis longicornis A5LHW1 isoform Pdi-3
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information protein disulfide isomerases are involved in blood feeding, viability and oocyte development, probably by mediating the formation of disulfide bond-containing proteins of the ticks and the formation of basement membrane and cuticle components such as extracellular matrix Haemaphysalis longicornis ?
-
?