Protein Variants | Comment | Organism |
---|---|---|
additional information | reduction of gene and protein expression by RNAi has no significant impact by itself. Injection of a combination of isoforms PDI-1/PDI-3 dsRNA has synergistic effects on tick viability. In PDI-1/PDI-3 dsRNA-injected ticks the midgut and cuticle are severely damaged. Disruption of PDI genes leads to a significant reduction of disulfide bond-containing vitellogenin expression in ticks | Haemaphysalis longicornis |
additional information | reduction of gene and protein expression by RNAi impacts tick blood feeding and oviposition. Injection of a combination of isoforms PDI-1/PDI-3 dsRNA has synergistic effects on tick viability. In PDI-1/PDI-3 dsRNA-injected ticks the midgut and cuticle are severely damaged. Disruption of PDI genes leads to a significant reduction of disulfide bond-containing vitellogenin expression in ticks | Haemaphysalis longicornis |
additional information | reduction of gene and protein expression by RNAi impacts tick viability. In PDI-2 dsRNA-injected ticks the midgut and cuticle are severely damaged. Disruption of PDI genes leads to a significant reduction of disulfide bond-containing vitellogenin expression in ticks | Haemaphysalis longicornis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Haemaphysalis longicornis | protein disulfide isomerases are involved in blood feeding, viability and oocyte development, probably by mediating the formation of disulfide bond-containing proteins of the ticks and the formation of basement membrane and cuticle components such as extracellular matrix | ? | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haemaphysalis longicornis | A5LHV9 | isoform Pdi-2 | - |
Haemaphysalis longicornis | A5LHW0 | isoform Pdi-1 | - |
Haemaphysalis longicornis | A5LHW1 | isoform Pdi-3 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | protein disulfide isomerases are involved in blood feeding, viability and oocyte development, probably by mediating the formation of disulfide bond-containing proteins of the ticks and the formation of basement membrane and cuticle components such as extracellular matrix | Haemaphysalis longicornis | ? | - |
? |