Application | Comment | Organism |
---|---|---|
medicine | inhibition of isoform procollagen-proline, 2-oxoglutarate-4-dioxygenase beta subunit activity increases apoptosis in response to agents which induce ER-stress such as fenretinide and velcade | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of isoform procollagen-proline, 2-oxoglutarate-4-dioxygenase beta subunit results in increased protein disulfide isomerase activity and abrogates the apoptosis-enhancing effect of inhibitor bacitracin. Overexpression of a mutant lacking protein disulfide isomerase activity does not increase cellular enzymic activity or block the effects of bacitracin | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bacitracin | inhibition of protein disulfide isomerase results in enhanced stress response and apoptosis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform procollagen-proline, 2-oxoglutarate-4-dioxygenase beta subunit | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-375 cell | - |
Homo sapiens | - |
CHL-1 cell | - |
Homo sapiens | - |
melanocyte | - |
Homo sapiens | - |
WM-266-4 cell | - |
Homo sapiens | - |