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Literature summary for 5.3.4.1 extracted from

  • Mahajan, B.; Noiva, R.; Yadava, A.; Zheng, H.; Majam, V.; Mohan, K.V.; Moch, J.K.; Haynes, J.D.; Nakhasi, H.; Kumar, S.
    Protein disulfide isomerase assisted protein folding in malaria parasites (2006), Int. J. Parasitol., 36, 1037-1048.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, expression of the enzyme fused to the human tissue plasminogen activator signal sequence in Escherichia coli strain DH10B Plasmodium berghei
DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, expression of the enzyme fused to the human tissue plasminogen activator signal sequence in Escherichia coli strain DH10B Plasmodium vivax
DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, expression of the enzyme fused to the human tissue plasminogen activator signal sequence in Escherichia coli strain DH10B Plasmodium knowlesi
DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, expression of the enzyme fused to the human tissue plasminogen activator signal sequence in Escherichia coli strain DH10B Plasmodium yoelii
isozymes PDI-8, PDI-9, PDI-11, and PDI-14, localization on chromosome-8, chromosome-9, chromosome-11, and chromosome-14, respectively, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, expression of the enzyme fused to the human tissue plasminogen activator signal sequence in Escherichia coli, strain DH10B Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum the enzyme contains a C-terminal endoplasmic reticulum retrieval signal, SEEL Plasmodium falciparum 5783
-
additional information stage-specific expression and cellular localization of isozymes, overview Plasmodium falciparum
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Plasmodium falciparum the enzyme assists protein folding in malaria parasites ?
-
?
additional information Plasmodium berghei the enzyme assists protein folding in malaria parasites ?
-
?
additional information Plasmodium vivax the enzyme assists protein folding in malaria parasites ?
-
?
additional information Plasmodium knowlesi the enzyme assists protein folding in malaria parasites ?
-
?
additional information Plasmodium yoelii the enzyme assists protein folding in malaria parasites ?
-
?
additional information Plasmodium berghei ANKA the enzyme assists protein folding in malaria parasites ?
-
?
additional information Plasmodium knowlesi H the enzyme assists protein folding in malaria parasites ?
-
?
additional information Plasmodium vivax Sal1 the enzyme assists protein folding in malaria parasites ?
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium berghei
-
isozyme PDI-8
-
Plasmodium berghei ANKA
-
isozyme PDI-8
-
Plasmodium falciparum
-
isozymes PDI-8, PDI-9, PDI-11, and PDI-14
-
Plasmodium knowlesi Q2XQR5 isozyme PDI-8
-
Plasmodium knowlesi H Q2XQR5 isozyme PDI-8
-
Plasmodium vivax Q2XQR3 isozyme PDI-8
-
Plasmodium vivax Sal1 Q2XQR3 isozyme PDI-8
-
Plasmodium yoelii Q7RRT0 isozyme PDI-8
-

Source Tissue

Source Tissue Comment Organism Textmining
gametocyte
-
Plasmodium falciparum
-
additional information stage-specific expression and cellular localization of isozymes, overview, isozyme PDI-8 is expressed during all stages of parasite life cycle Plasmodium falciparum
-
schizont
-
Plasmodium falciparum
-
sporozoite
-
Plasmodium falciparum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme assists protein folding in malaria parasites Plasmodium falciparum ?
-
?
additional information the enzyme assists protein folding in malaria parasites Plasmodium berghei ?
-
?
additional information the enzyme assists protein folding in malaria parasites Plasmodium vivax ?
-
?
additional information the enzyme assists protein folding in malaria parasites Plasmodium knowlesi ?
-
?
additional information the enzyme assists protein folding in malaria parasites Plasmodium yoelii ?
-
?
additional information the enzyme is a potent oxido-reductase and facilitates the disulfide-dependent conformational folding of EBA-175, the enzyme contain two CGHC active sites within two thioredoxin domains Plasmodium falciparum ?
-
?
additional information the enzyme is a potent oxido-reductase and facilitates the disulfide-dependent conformational folding of EBA-175, the enzyme contain two CGHC active sites within two thioredoxin domains Plasmodium berghei ?
-
?
additional information the enzyme is a potent oxido-reductase and facilitates the disulfide-dependent conformational folding of EBA-175, the enzyme contain two CGHC active sites within two thioredoxin domains Plasmodium vivax ?
-
?
additional information the enzyme is a potent oxido-reductase and facilitates the disulfide-dependent conformational folding of EBA-175, the enzyme contain two CGHC active sites within two thioredoxin domains Plasmodium knowlesi ?
-
?
additional information the enzyme is a potent oxido-reductase and facilitates the disulfide-dependent conformational folding of EBA-175, the enzyme contains two CGHC active sites within two thioredoxin domains Plasmodium yoelii ?
-
?
additional information the enzyme assists protein folding in malaria parasites Plasmodium berghei ANKA ?
-
?
additional information the enzyme is a potent oxido-reductase and facilitates the disulfide-dependent conformational folding of EBA-175, the enzyme contain two CGHC active sites within two thioredoxin domains Plasmodium berghei ANKA ?
-
?
additional information the enzyme assists protein folding in malaria parasites Plasmodium knowlesi H ?
-
?
additional information the enzyme is a potent oxido-reductase and facilitates the disulfide-dependent conformational folding of EBA-175, the enzyme contain two CGHC active sites within two thioredoxin domains Plasmodium knowlesi H ?
-
?
additional information the enzyme assists protein folding in malaria parasites Plasmodium vivax Sal1 ?
-
?
additional information the enzyme is a potent oxido-reductase and facilitates the disulfide-dependent conformational folding of EBA-175, the enzyme contain two CGHC active sites within two thioredoxin domains Plasmodium vivax Sal1 ?
-
?

Subunits

Subunits Comment Organism
More structural analysis and comparison of PDIs from different Plasmodium species Plasmodium falciparum
More structural analysis and comparison of PDIs from different Plasmodium species Plasmodium berghei
More structural analysis and comparison of PDIs from different Plasmodium species Plasmodium vivax
More structural analysis and comparison of PDIs from different Plasmodium species Plasmodium knowlesi
More structural analysis and comparison of PDIs from different Plasmodium species Plasmodium yoelii

Synonyms

Synonyms Comment Organism
PDI
-
Plasmodium falciparum
PDI
-
Plasmodium berghei
PDI
-
Plasmodium vivax
PDI
-
Plasmodium knowlesi
PDI
-
Plasmodium yoelii
protein disulfide isomerase
-
Plasmodium falciparum
protein disulfide isomerase
-
Plasmodium berghei
protein disulfide isomerase
-
Plasmodium vivax
protein disulfide isomerase
-
Plasmodium knowlesi
protein disulfide isomerase
-
Plasmodium yoelii