Cloned (Comment) | Organism |
---|---|
expression of His-tagged PDI in Escherichia coli periplasmic space | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
protein DS61 | - |
Plasmodium falciparum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Plasmodium falciparum | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
strains 3D7 and FcB1, isozyme PDI-22 | - |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged PDI from Escherichia coli by nickel affinnity chromatography | Plasmodium falciparum |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | PDI expression during parasite development, overview | Plasmodium falciparum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
insulin | bovine substrate, reduction of disulfide bonds | Plasmodium falciparum | ? | - |
? | |
additional information | the enzyme shows disulfide oxidase/isomerase, reductase, and chaperone activities, overview | Plasmodium falciparum | ? | - |
? | |
rhodanese | the protein substrate is devoid of disulfide bonds, chaperone activity | Plasmodium falciparum | ? | - |
? | |
RNase A | reduced and denatured substrate, oxidase/isomerase activity on the refolding of the substrate | Plasmodium falciparum | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | predominantly, isozyme PDI-22, SDS-PAGE and gel filtration | Plasmodium falciparum |
Synonyms | Comment | Organism |
---|---|---|
PDI | - |
Plasmodium falciparum |
protein disulfide isomerase | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.43 | - |
isozyme PDI-22 | Plasmodium falciparum | protein DS61 |