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Literature summary for 5.3.4.1 extracted from

  • Bell, S.E.; Shah, C.M.; Gordge, M.P.
    Protein disulfide-isomerase mediates delivery of nitric oxide redox derivatives into platelets (2007), Biochem. J., 403, 283-288.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.4.1

Inhibitors

Inhibitors Comment Organism Structure
bacitracin
-
 Homo sapiens
additional information inhibition by PDI-specific antibodiy RL90 Homo sapiens
Phenylarsine oxide complete inhibition at 0.01-0.1 mM in vivo Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme mediates rapid delivery of NO signalling into human platelets from the S-nitrosothiol compound S-nitrosoglutathione, NO delivery is blocked by inhibition of PDI, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme mediates rapid delivery of NO signalling into human platelets from the S-nitrosothiol compound S-nitrosoglutathione, NO delivery is blocked by inhibition of PDI, overview Homo sapiens ?
-
 ?
additional information the enzyme shows disulfide exchange activity Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PDI
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 in vivo assay at Homo sapiens