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Literature summary for 5.3.4.1 extracted from
- ERp57 and PDI: multifunctional protein disulfide isomerases with similar domain architectures but differing substrate-partner associations (2006), Biochem. Cell Biol., 84, 881-889.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme is stress-inducible | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| sequence comparison | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme is involved in correct disulfide bond formation in secretory proteins as a key step in endoplasmic reticulum quality control, ERp57 works in conjunction with the endoplasmic reticulum lectin-like chaperones calnexin and calreticulin via the noncatalytic b' domain of the enzyme, the b' domains of ERp57 and PDI are very different, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P07237 | PDIA1 | - |
| Homo sapiens | P13667 | ERp72 or PDIA4, respecitvely | - |
| Homo sapiens | P30101 | ERp57 | - |
| Homo sapiens | Q13087 | PDIA2 precursor | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | inducible | Homo sapiens | - |
| additional information | ubiquitous tissue expression | Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is involved in correct disulfide bond formation in secretory proteins as a key step in endoplasmic reticulum quality control, ERp57 works in conjunction with the endoplasmic reticulum lectin-like chaperones calnexin and calreticulin via the noncatalytic b' domain of the enzyme, the b' domains of ERp57 and PDI are very different, overview | Homo sapiens | ? | - |
? | |
| additional information | the enzyme catalyzes the oxidation, reduction, and isomerization of secretory proteins and plasma membrane proteins, substrate specificity, the enzyme contains a WCGHC active site, overview | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | domain structure of isozymes, comparison, overview | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ERp57 | - |
Homo sapiens |
| ERp72 | - |
Homo sapiens |
| More | the enzyme belongs to the protein disulfide isomerase family | Homo sapiens |
| multifunctional protein disulfide isomerase | - |
Homo sapiens |
| PDIA1 | - |
Homo sapiens |
| PDIA2 | - |
Homo sapiens |
| PDIA4 | - |
Homo sapiens |
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