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Literature summary for 5.3.4.1 extracted from

  • Bellisola, G.; Fracasso, G.; Ippoliti, R.; Menestrina, G.; Rosen, A.; Solda, S.; Udali, S.; Tomazzolli, R.; Tridente, G.; Colombatti, M.
    Reductive activation of ricin and ricin A-chain immunotoxins by protein disulfide isomerase and thioredoxin reductase (2004), Biochem. Pharmacol., 67, 1721-1731.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
DTT the disulfide reduction activity of PDI-DTT is reduced Bos taurus
additional information thioredoxin reductase activates PDI at pH 7.4, 37°C involving glutathione reduction and NADPH, the disulfide reduction activity of PDI-thioredoxin reductase is reduced Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Bos taurus 5783
-
membrane
-
Bos taurus 16020
-
microsome
-
Bos taurus
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation liver enzyme Bos taurus
-
liver
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GSSG disulfide reduction of GSSG, the disulfide reduction activity of both PDI-thioredoxin reductase and PDI-DTT is reduced Bos taurus GSH
-
?
additional information PDI is a better thiol oxidant than a disulfide protein reductant Bos taurus ?
-
?
ricin reductive activation of ricin and ricin A-chain immunotoxins, assay system involving thioredoxin reductase and NADPH, overview Bos taurus ?
-
?
ricin A-chain immunotoxins reductive activation of ricin and ricin A-chain immunotoxins, assay system involving thioredoxin reductase and NADPH, overview Bos taurus ?
-
?

Synonyms

Synonyms Comment Organism
PDI
-
Bos taurus
protein disulfide isomerase
-
Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Bos taurus