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Literature summary for 5.3.4.1 extracted from
- The role of calcium on the activity of ERcalcistorin/protein-disulfide isomerase and the significance of the C-terminal and its calcium binding. A comparison with mammalian protein-disulfide isomerase (1999), J. Biol. Chem., 274, 3243-3251.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| endoplasmic reticulum | - |
Echinoidea | 5783 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 1-5 mM Ca2+ augments the reactivation of reduced bovine pancreatic trypsin inhibitor | Oryctolagus cuniculus |  |
| Ca2+ | enzyme binds 23 mol Ca2+ at low affinity | Echinoidea | |
| Ca2+ | recombinant ECaST/PDI binds 26 mol of Ca2+/mol of protein with a Kd of 2.8 mM, 1-5 mM Ca2+ augments the reactivation of rBPTI | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 58000 | - |
x * 58000, recombinant ECaSt/PDI, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Echinoidea | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Oryctolagus cuniculus |
- |
Echinoidea |
| recombinant enzyme | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| unfolded bovine pancreatic trypsin inhibitor | - |
Homo sapiens | refolded bovine pancreatic trypsin inhibitor | - |
? | |
| unfolded bovine pancreatic trypsin inhibitor | - |
Oryctolagus cuniculus | refolded bovine pancreatic trypsin inhibitor | - |
? | |
| unfolded bovine pancreatic trypsin inhibitor | - |
Echinoidea | refolded bovine pancreatic trypsin inhibitor | - |
? | |
| unfolded insulin + reduced glutathione | - |
Homo sapiens | refolded insulin + oxidized glutathione | - |
? | |
| unfolded rRNaSe | refolding of reduced rRNaSe | Homo sapiens | refolded rRNase | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 58000, recombinant ECaSt/PDI, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ECaSt/PDI | - |
Oryctolagus cuniculus |
| ERcalcistorin/protein-disulfide isomerase | - |
Oryctolagus cuniculus |
| ERcalcistorin/protein-disulfide isomerase | i.e. ECaSt/PDI | Homo sapiens |
| ERcalcistorin/protein-disulfide isomerase | i.e. ECaSt/PDI | Echinoidea |
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Release 2023.1 (January 2023)
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